The Best Southern Garlic Parmesan Chicken Penne Recipe

There’s something timeless and irresistible about creamy pasta dishes—especially when they combine the rustic charm of Southern cooking with the rich, satisfying flavors of garlic and cheese. This Southern Garlic Parmesan Chicken Penne is the kind of meal that feels like home. Whether you’re preparing dinner on a chilly weeknight, feeding a hungry family after a long day, or simply craving a bowl of bold, creamy comfort, this dish delivers.

The inspiration behind this recipe stems from the heart of Southern kitchens, where simplicity meets soul. Drawing from beloved staples like cheddar, smoked paprika, and a hint of Cajun seasoning, this pasta takes traditional garlic Parmesan sauce to the next level. Add juicy seared chicken and tender penne, and you have a one-pan masterpiece that’s both easy to make and unforgettable to taste.

Let’s dive into everything you need to know to master this creamy, cheesy, Southern-style pasta.

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Why You’ll Love This Recipe

• Bold, creamy flavor with a Southern twist – The rich garlic-Parmesan sauce gets an upgrade with smoked paprika, cheddar, and optional Cajun spice.

• Quick and easy – Ready in just 30 minutes, perfect for weeknight dinners.

• Hearty and satisfying – Chicken and pasta combine for a filling, protein-packed meal.

• One-pan convenience – Minimal cleanup and maximum flavor.

• Customizable – Easily adjust the seasoning or cheese blend to suit your preferences.

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Ingredients

To create the perfect Southern Garlic Parmesan Chicken Penne, gather the following simple, wholesome ingredients:

• 12 oz penne pasta

• 1 lb boneless skinless chicken breast, cut into strips

• Salt & black pepper, to taste

• 1 tsp garlic powder

• 1 tsp smoked paprika

• 1 tsp Cajun seasoning (optional, for added heat)

• 2 tbsp olive oil

• 3 tbsp unsalted butter

• 4 cloves garlic, minced

• 1 cup heavy cream

• ½ cup chicken broth

• ¾ cup grated Parmesan cheese

• 1 cup shredded cheddar cheese

• 1 tsp dried parsley (or 1 tbsp fresh chopped parsley)

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Directions

Follow these step-by-step instructions for a creamy, flavorful chicken penne dish:

1. Cook the Pasta

Start by cooking the penne pasta according to the package instructions. Drain and set it aside.

2. Season the Chicken

While the pasta is cooking, season the chicken strips with salt, pepper, garlic powder, smoked paprika, and Cajun seasoning (if using). This mix infuses the chicken with a deep, smoky Southern flavor.

3. Sear the Chicken

In a large skillet over medium-high heat, heat the olive oil. Add the seasoned chicken and cook until golden brown and fully cooked through—about 6–7 minutes. Once done, transfer the chicken to a plate and set aside.

4. Build the Garlic Parmesan Sauce

In the same skillet (don’t clean it—the browned bits add flavor), melt the butter over medium heat. Add the minced garlic and sauté for about 1 minute until fragrant.

5. Add Cream and Broth

Pour in the heavy cream and chicken broth, stirring to combine. Simmer for 3–4 minutes to slightly reduce and thicken the sauce.

6. Melt in the Cheeses

Lower the heat slightly, then stir in the grated Parmesan and shredded cheddar cheese. Keep stirring until the sauce is smooth, velvety, and thick.

7. Combine Chicken and Pasta

Add the cooked penne and seared chicken back to the skillet. Toss well to ensure every bite is coated in the luscious sauce.

8. Garnish and Serve

Sprinkle with dried (or fresh) parsley for a pop of color and a final touch of flavor. Serve hot and enjoy.

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Tips for Success

Choose Quality Cheese

Using freshly grated Parmesan and cheddar cheese (instead of pre-shredded) enhances the sauce’s texture and flavor. Pre-shredded cheeses often contain anti-caking agents that can make the sauce grainy.

Don’t Skip the Cajun Seasoning

If you enjoy a touch of heat, the Cajun seasoning adds a bold Southern kick that complements the creamy garlic base beautifully. Want it spicier? Add a pinch of crushed red pepper flakes.

Use Fresh Garlic

While garlic powder seasons the chicken, using fresh garlic in the sauce is essential for its robust, aromatic flavor. Mince it finely so it blends smoothly into the cream.

Let the Sauce Simmer

Give your cream and broth a few minutes to simmer before adding cheese. This slight reduction helps the sauce thicken and allows the flavors to meld.

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Ingredient Substitutions & Variations

Pasta Choices

• Penne is ideal for holding the creamy sauce, but feel free to substitute with rotini, rigatoni, or bowties.

Chicken Swaps

• Use chicken thighs instead of breast for a richer flavor.

• For a meat-free version, substitute the chicken with sautéed mushrooms or grilled zucchini.

Cheese Combos

• Add mozzarella for extra creaminess.

• Swap cheddar for Monterey Jack or Colby for a milder taste.

Herb Options

• Try fresh basil, thyme, or chives instead of parsley to personalize the herb finish.

Add-Ins

• Spinach: Stir in a handful of fresh spinach before serving for a pop of green.

• Sun-dried tomatoes: A few chopped sun-dried tomatoes add sweetness and complexity.

• Roasted red peppers: Adds smokiness and vibrant color.

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Perfect Pairings

Wondering what to serve with this dish? Here are a few side suggestions:

• Garlic Bread – Because more garlic is always welcome.

• Simple Green Salad – A crisp salad with lemon vinaigrette balances the rich pasta.

• Roasted Vegetables – Roasted broccoli, Brussels sprouts, or carrots bring earthiness to the meal.

• Southern-Style Sweet Tea – Keep the theme going with a tall glass of refreshing sweet tea.

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Make-Ahead & Storage Instructions

Make-Ahead Tips

You can prep most components of this dish in advance:

• Cook and season the chicken, then store it in the fridge.

• Cook the pasta and toss it with a little olive oil to prevent sticking.

• Prepare the sauce up to a day in advance and gently reheat when combining.

Storing Leftovers

Store any leftovers in an airtight container in the refrigerator for up to 4 days.

Reheating

Reheat gently over low heat on the stove, adding a splash of milk or broth to loosen the sauce. You can also microwave in 30-second intervals, stirring in between.

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How to Make It a Family Favorite

This dish already checks all the boxes for family appeal—cheesy, creamy, and hearty. But here are a few ways to make it even more of a hit:

• Let kids help by stirring the pasta or sprinkling on the parsley.

• Make it mild by omitting the Cajun seasoning for younger palates.

• Double the batch and refrigerate or freeze leftovers for a busy weeknight meal.

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Why This Recipe Works

Every element of this dish is thoughtfully balanced. The cream-based sauce is enriched with two kinds of cheese for complexity, while garlic provides depth. The smoked paprika adds a hint of barbecue-style warmth, and the optional Cajun seasoning ties it all together with bold Southern spirit. By searing the chicken first and then building the sauce in the same pan, you layer flavors that result in a dish that tastes like it took hours to make—but only takes 30 minutes.

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